More generally, excessive behavioral inhibition (i.e., highHarmAvoidance) predisposes individuals to anxiety, depression, and low self-esteem.
Individuals who are high in both Harm Avoidance and Novelty Seeking are expected to have frequent approach–avoidance conflicts, as seen in cycles of binging and purging in bulimia. Individual differences in temperament and basic emotions modify the processing of sensory information and shape early learning characteristics, especially associative conditioning of unconscious behavior responses. mature motivation develops after basic needs are met and the person is freed to experience numerous secondary motives for growth in character and in selfawareness. Temperamental differences, which are not very stable initially, tend to stabilize during the second and third years of life. Excessive fear and anger, associated with temperament, are motivationally monopolistic and take over the personality by altering perception, learning, and behavior in a biased way. Temperament traits do not show rapid changes with increasing age. 
These four temperament traits are closely associated with the four basic emotions of fear (Harm Avoidance), anger (Novelty Seeking), attachment (Reward Dependence), and ambition (Persistence).Roughly speaking temperament involves emotions, character- rational concepts about self and interpersonal relations & psyche- intuitive self awareness & fluid intelligence.
30 to 35 percent is explained by nonshared environmental effects (i.e., influences unique to each individual).
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